Chlorhexidine Digluconate Formulations Used for Skin Antisepsis

Gelatin as a Chlorhexidine Digluconate Immobilizing Agent

Periodontal diseases are a diversified group of clinical entities, described as pathologies of a multifactorial nature, in which the induction of an inflammatory process that destroys the fixation apparatus, loss of the alveolar bone and, if untreated, in the loss of the dental element. Among the wide variety of drugs used in the treatment of periodontal disease, chlorhexidine demonstrated to b...

Miconazole Nitrate Nanocrystals Combined with Chlorhexidine Digluconate for Improved Treatment of Fungal Skin Diseases

Pitfalls in evidence assessment: the case of chlorhexidine and alcohol in skin antisepsis.

Chlorhexidine has attracted increasing attention for its role in skin antisepsis in recent years. It was tested in several prominent clinical trials and subsequently recommended in important guidelines for blood culture collection, vascular catheter insertion and surgical skin preparation. We noticed and subsequently reported a widespread misinterpretation of evidence surrounding chlorhexidine ...

Experimental evaluation of chlorhexidine gluconate for ocular antisepsis.

Chlorhexidine gluconate is a bisguanide germicide currently available with 70% isopropanol (Hibistat, Hibitane) or a detergent (Hibiclens, Hibiscrub) for preoperative skin preparation. As these solvents are toxic to the cornea, we investigated the safety and efficacy of aqueous chlorhexidine solutions for ophthalmic use. Chlorhexidine in Tris-glycine buffer was evaluated for retardation of epit...

Chlorhexidine-Alcohol versus Povidone-Iodine for Surgical-Site Antisepsis.

BACKGROUND Since the patient's skin is a major source of pathogens that cause surgical-site infection, optimization of preoperative skin antisepsis may decrease postoperative infections. We hypothesized that preoperative skin cleansing with chlorhexidine-alcohol is more protective against infection than is povidone-iodine. METHODS We randomly assigned adults undergoing clean-contaminated surg...